Ontology highlight
ABSTRACT:
SUBMITTER: King BM
PROVIDER: S-EPMC3465721 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
King Bracken M BM Silver Nathaniel W NW Tidor Bruce B
The journal of physical chemistry. B 20120222 9
Accurate computation of free energy changes upon molecular binding remains a challenging problem, and changes in configurational entropy are especially difficult due to the potentially large numbers of local minima, anharmonicity, and high-order coupling among degrees of freedom. Here we propose a new method to compute molecular entropies based on the maximum information spanning tree (MIST) approximation that we have previously developed. Estimates of high-order couplings using only low-order t ...[more]