Memantine shows promise in reducing gambling severity and cognitive inflexibility in pathological gambling: a pilot study.
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ABSTRACT:
SUBMITTER: Grant JE
PROVIDER: S-EPMC3465841 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
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Memantine shows promise in reducing gambling severity and cognitive inflexibility in pathological gambling: a pilot study.
Grant Jon E JE Chamberlain Samuel R SR Odlaug Brian L BL Potenza Marc N MN Kim Suck Won SW
Psychopharmacology 20100819 4
<h4>Rationale</h4>Although pathological gambling (PG) is relatively common, pharmacotherapy research for PG is limited. Memantine, an N-methyl D-aspartate receptor antagonist, appears to reduce glutamate excitability and improve impulsive decision making, suggesting it may help individuals with PG.<h4>Objective</h4>This study sought to examine the safety and efficacy of Memantine in PG.<h4>Methods</h4>Twenty-nine subjects (18 females) with DSM-IV PG were enrolled in a 10-week open-label treatmen ...[more]
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