Ontology highlight
ABSTRACT:
SUBMITTER: Halaszovich CR
PROVIDER: S-EPMC3465996 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Journal of lipid research 20120815 11
In voltage-sensitive phosphatases (VSPs), a transmembrane voltage sensor domain (VSD) controls an intracellular phosphoinositide phosphatase domain, thereby enabling immediate initiation of intracellular signals by membrane depolarization. The existence of such a mechanism in mammals has remained elusive, despite the presence of VSP-homologous proteins in mammalian cells, in particular in sperm precursor cells. Here we demonstrate activation of a human VSP (hVSP1/TPIP) by an intramolecular switc ...[more]