Dataset Information

BioFET-SIM web interface: implementation and two applications.

ABSTRACT: We present a web interface which allows us to conveniently set up calculations based on the BioFET-SIM model. With the interface, the signal of a BioFET sensor can be calculated depending on its parameters, as well as the signal dependence on pH. As an illustration, two case studies are presented. In the first case, a generic peptide with opposite charges on both ends is inverted in orientation on a semiconducting nanowire surface leading to a corresponding change in sign of the computed sensitivity of the device. In the second case, the binding of an antibody/antigen complex on the nanowire surface is studied in terms of orientation and analyte/nanowire surface distance. We demonstrate how the BioFET-SIM web interface can aid in the understanding of experimental data and postulate alternative ways of antibody/antigen orientation on the nanowire surface.

SUBMITTER: Hediger MR

PROVIDER: S-EPMC3466287 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Publications

BioFET-SIM web interface: implementation and two applications.

Hediger Martin R MR Jensen Jan H JH De Vico Luca L

PloS one 20121008 10

We present a web interface which allows us to conveniently set up calculations based on the BioFET-SIM model. With the interface, the signal of a BioFET sensor can be calculated depending on its parameters, as well as the signal dependence on pH. As an illustration, two case studies are presented. In the first case, a generic peptide with opposite charges on both ends is inverted in orientation on a semiconducting nanowire surface leading to a corresponding change in sign of the computed sensiti ...[more]

PMID: 23056201

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Dataset Information

BioFET-SIM web interface: implementation and two applications.

Publications

BioFET-SIM web interface: implementation and two applications.

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