Ontology highlight
ABSTRACT:
SUBMITTER: Stoermer KA
PROVIDER: S-EPMC3466331 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Stoermer Kristina A KA Burrack Adam A Oko Lauren L Montgomery Stephanie A SA Borst Luke B LB Gill Ronald G RG Morrison Thomas E TE
Journal of immunology (Baltimore, Md. : 1950) 20120912 8
Chikungunya virus (CHIKV) and Ross River virus (RRV) cause a debilitating, and often chronic, musculoskeletal inflammatory disease in humans. Macrophages constitute the major inflammatory infiltrates in musculoskeletal tissues during these infections. However, the precise macrophage effector functions that affect the pathogenesis of arthritogenic alphaviruses have not been defined. We hypothesized that the severe damage to musculoskeletal tissues observed in RRV- or CHIKV-infected mice would pro ...[more]