Ontology highlight
ABSTRACT:
SUBMITTER: Call ME
PROVIDER: S-EPMC3466601 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Call Matthew E ME Schnell Jason R JR Xu Chenqi C Lutz Regina A RA Chou James J JJ Wucherpfennig Kai W KW
Cell 20061001 2
The T cell receptor (TCR) alphabeta heterodimer communicates ligand binding to the cell interior via noncovalently associated CD3gammaepsilon, CD3deltaepsilon, and zetazeta dimers. While structures of extracellular components of the TCR-CD3 complex are known, the transmembrane (TM) domains that mediate assembly have eluded structural characterization. Incorporation of the zetazeta signaling module is known to require one basic TCRalpha and two zetazeta aspartic acid TM residues. We report the NM ...[more]