Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC3467061 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Kim Junil J Choi Minsoo M Kim Jeong-Rae JR Jin Hua H Kim V Narry VN Cho Kwang-Hyun KH
Nucleic acids research 20120713 18
The co-regulation of transcription factors (TFs) has been widely observed in various species. Why is such a co-regulation mechanism needed for transcriptional regulation? To answer this question, the following experiments and analyses were performed. First, examination of the human gene regulatory network (GRN) indicated that co-regulation was significantly enriched in the human GRN. Second, mathematical simulation of an artificial regulatory network showed that the co-regulation mechanism was r ...[more]