Ontology highlight
ABSTRACT:
SUBMITTER: Bolla JR
PROVIDER: S-EPMC3467072 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Bolla Jani Reddy JR Do Sylvia V SV Long Feng F Dai Lei L Su Chih-Chia CC Lei Hsiang-Ting HT Chen Xiao X Gerkey Jillian E JE Murphy Daniel C DC Rajashankar Kanagalaghatta R KR Zhang Qijing Q Yu Edward W EW
Nucleic acids research 20120719 18
The Mmr multidrug efflux pump recognizes and actively extrudes a broad range of antimicrobial agents, and promotes the intrinsic resistance to these antimicrobials in Mycobacterium tuberculosis. The expression of Mmr is controlled by the TetR-like transcriptional regulator Rv3066, whose open reading frame is located downstream of the mmr operon. To understand the structural basis of Rv3066 regulation, we have determined the crystal structures of Rv3066, both in the absence and presence of bound ...[more]