Ontology highlight
ABSTRACT:
SUBMITTER: Lodhi IJ
PROVIDER: S-EPMC3467338 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Lodhi Irfan J IJ Yin Li L Jensen-Urstad Anne P L AP Funai Katsuhiko K Coleman Trey T Baird John H JH El Ramahi Meral K MK Razani Babak B Song Haowei H Fu-Hsu Fong F Turk John J Semenkovich Clay F CF
Cell metabolism 20120801 2
De novo lipogenesis in adipocytes, especially with high fat feeding, is poorly understood. We demonstrate that an adipocyte lipogenic pathway encompassing fatty acid synthase (FAS) and PexRAP (peroxisomal reductase activating PPARγ) modulates endogenous PPARγ activation and adiposity. Mice lacking FAS in adult adipose tissue manifested increased energy expenditure, increased brown fat-like adipocytes in subcutaneous adipose tissue, and resistance to diet-induced obesity. FAS knockdown in embryon ...[more]