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Association of GSTM1 null allele with prostate cancer risk: evidence from 36 case-control studies.

ABSTRACT: BACKGROUND: Glutathione S-transferase M1 (GSTM1) is thought to be involved in detoxifying several carcinogens and may play a vital role in tumorigenesis. Numerous studies have evaluated the association between GSTM1 null/present polymorphism and risk of prostate cancer (PCa). However, the results remain inconsistent. To derive a more precise estimation, we performed a meta-analysis. METHODOLOGY/PRINCIPAL FINDINGS: A comprehensive search was conducted to identify all eligible case-control studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. The overall association was significant (OR?=?1.28, 95% CI: 1.11-1.48, P?=?0.001). Moreover, subgroup analyses showed GSTM1 null genotype significantly associated with PCa risk among Asians (OR?=?1.35, 95% CI: 1.03-1.78, P?=?0.03) but not among Caucasians (OR?=?1.12, 95% CI: 0.96-1.31, P?=?0.16). In addition, we did not find that smoking modified the genotype effect on the risk of PCa. CONCLUSIONS/SIGNIFICANCE: The present meta-analysis suggested that GSTM1 null allele was a low-penetrant risk factor for PCa among Asians.

SUBMITTER: Wei B

PROVIDER: S-EPMC3468624 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Association of GSTM1 null allele with prostate cancer risk: evidence from 36 case-control studies.

Wei Bingbing B Xu Zhuoqun Z Zhou You Y Ruan Jun J Cheng Huan H Xi Bo B Zhu Ming M Jin Ke K Zhou Deqi D Hu Qiang Q Wang Qiang Q Wang Zhirong Z Yan Zhiqiang Z Xuan Feng F Huang Xing X Zhang Jian J Zhou Hongyi H

PloS one 20121010 10

<h4>Background</h4>Glutathione S-transferase M1 (GSTM1) is thought to be involved in detoxifying several carcinogens and may play a vital role in tumorigenesis. Numerous studies have evaluated the association between GSTM1 null/present polymorphism and risk of prostate cancer (PCa). However, the results remain inconsistent. To derive a more precise estimation, we performed a meta-analysis.<h4>Methodology/principal findings</h4>A comprehensive search was conducted to identify all eligible case-co ...[more]

PMID: 23071687

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Project description:BackgroundIt is well known that hepatocellular carcinoma (HCC) has been one of the most life-threatening diseases all over the world. Plenty of internal and extrinsic factors have been proven to be related to HCC, such as gene mutation, viral hepatitis, and Nitrosamines. Though previous studies demonstrated that glutathione S-transferase (GST) genotypes are associated with HCC, the conclusions are inconsistent. Therefore, we carried on a renewed meta-analysis to expound the connection between the null GSTM1, GSTT1 polymorphisms and the risk of HCC.MethodsWe searched PubMed, Web of Science, Embase, and CNKI databases to select qualified researches which satisfied the inclusion criteria up to July 31, 2018. Finally, we selected 41 articles with 6124 cases and 9781 controls in this meta-analysis. We use ORs and 95% confidence interval (CI) to evaluate the correlation intension between the GSTM1 and GSTT1 null genes and the risk of HCC. All the statistical processes were executed by Stata (version 12.0).ResultsThe pooled analysis showed that both GSTM1 null genotypes (OR = 1.37, 95% CI = 1.18-1.59) and GSTT1 null genotypes (OR = 1.43, 95% CI = 1.23-1.66) increased the risk of HCC. And GSTM1-GSTT1 dual-null genotypes also increased the risk of HCC (OR = 1.58, 95% CI = 1.22-2.05). In the subgroup analysis, we obtained significant results among Asians when stratified by race, and the results are GSTM1 null OR = 1.44, 95% CI = (1.22-1.71), GSTT1 null OR = 1.48, 95% CI = (1.25-1.77), GSTM1-GSTT1 null OR = 1.58, 95% CI = (1.19-2.09), while we didn't obtain significant results among Caucasians or Africans. Stratified analyses on the type of control indicated a higher risk of HCC associated with GSTM1, GSTT1 single null genotypes and GSTM1-GSTT1 dual-null genotypes in healthy people. No evidence of significant connection was discovered in chronic liver disease (CLD) except in GSTT1 single null.ConclusionsOur study indicated that an individual who carries the GSTM1, GSTT1 single null genotypes and GSTT1-GSTM1 dual-null genotypes is more likely to develop HCC.

Dataset Information

Association of GSTM1 null allele with prostate cancer risk: evidence from 36 case-control studies.

Publications

Association of GSTM1 null allele with prostate cancer risk: evidence from 36 case-control studies.

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