Ontology highlight
ABSTRACT:
SUBMITTER: Jeong DW
PROVIDER: S-EPMC3468659 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Jeong Do-Won DW Cho Hoonsik H Jones Marcus B MB Shatzkes Kenneth K Sun Fei F Ji Quanjiang Q Liu Qian Q Peterson Scott N SN He Chuan C Bae Taeok T
Molecular microbiology 20120827 2
In bacterial two-component regulatory systems (TCSs), dephosphorylation of phosphorylated response regulators is essential for resetting the activated systems to the pre-activation state. However, in the SaeRS TCS, a major virulence TCS of Staphylococcus aureus, the mechanism for dephosphorylation of the response regulator SaeR has not been identified. Here we report that two auxiliary proteins from the sae operon, SaeP and SaeQ, form a protein complex with the sensor kinase SaeS and activate th ...[more]