Amyloid-β assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study.

ABSTRACT:

Objectives

Florbetapir F 18 PET can image amyloid-β (Aβ) aggregates in the brains of living subjects. We prospectively evaluated the prognostic utility of detecting Aβ pathology using florbetapir PET in subjects at risk for progressive cognitive decline.

Methods

A total of 151 subjects who previously participated in a multicenter florbetapir PET imaging study were recruited for longitudinal assessment. Subjects included 51 with recently diagnosed mild cognitive impairment (MCI), 69 cognitively normal controls (CN), and 31 with clinically diagnosed Alzheimer disease dementia (AD). PET images were visually scored as positive (Aβ+) or negative (Aβ-) for pathologic levels of β-amyloid aggregation, blind to diagnostic classification. Cerebral to cerebellar standardized uptake val

SUBMITTER: Doraiswamy PM 

PROVIDER: S-EPMC3468774 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature