Ontology highlight
ABSTRACT:
SUBMITTER: Demachi-Okamura A
PROVIDER: S-EPMC3469533 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Demachi-Okamura Ayako A Torikai Hiroki H Akatsuka Yoshiki Y Miyoshi Hiroyuki H Yoshimori Tamotsu T Kuzushima Kiyotaka K
PloS one 20121011 10
The detailed mechanisms responsible for processing tumor-associated antigens and presenting them to CTLs remain to be fully elucidated. In this study, we demonstrate a unique CTL epitope generated from the ubiquitous protein puromycin-sensitive aminopeptidase, which is presented via HLA-A24 on leukemic and pancreatic cancer cells but not on normal fibroblasts or EBV-transformed B lymphoblastoid cells. The generation of this epitope requires proteasomal digestion and transportation from the endop ...[more]