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(8aR,9R)-9-Hy-droxy-7,8,8a,9-tetra-hydro-furo[3,2-f]indolizin-6(4H)-one.

ABSTRACT: The title compound, C(10)H(11)NO(3), crystallizes with four independent mol-ecules in the asymmetric unit. Their geometries are very similar and corresponding bond distances are almost identical. The central six-membered ring of the indolizine moiety adopts a envelope conformation [the displacement of the flap atom (the C atom opposite the N atom) being 0.539?(2), 0.548?(3), 0.509?(3) and 0.544?(3)?Å in the four molecules], while the conformation of the oxopyrrolidine ring is close to that of a flat envelope. The displacements of the non-fused C atom opposite the C=O group of the pyrrolidine ring of the four mol-ecules are 0.366?(3), 0.335?(3), 0.173?(3) and -0.310?(3)?Å. In the crystal, O-H?O hydrogen bonds link the mol-ecules into chains, which run parallel to the c axis. The absolute configuration was assigned from the synthesis.

SUBMITTER: Vrabel V

PROVIDER: S-EPMC3470388 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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(8aR,9R)-9-Hy-droxy-7,8,8a,9-tetra-hydro-furo[3,2-f]indolizin-6(4H)-one.

Vrábel Viktor V Svorc Lubomír L Safář Peter P Sivý Július J Jozefína Zúžiová Z

Acta crystallographica. Section E, Structure reports online 20120929 Pt 10

The title compound, C(10)H(11)NO(3), crystallizes with four independent mol-ecules in the asymmetric unit. Their geometries are very similar and corresponding bond distances are almost identical. The central six-membered ring of the indolizine moiety adopts a envelope conformation [the displacement of the flap atom (the C atom opposite the N atom) being 0.539 (2), 0.548 (3), 0.509 (3) and 0.544 (3) Å in the four molecules], while the conformation of the oxopyrrolidine ring is close to that of a ...[more]

PMID: 23125801

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