Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study.

ABSTRACT:

Background

Although fluoroquinolones are sometimes associated with mild, transient elevations in aminotransferase levels, serious acute liver injury is uncommon. Regulatory warnings have identified moxifloxacin as presenting a particular risk of hepatotoxicity. Thus, we examined the risk of idiosyncratic acute liver injury associated with the use of moxifloxacin relative to other selected antibiotic agents.

Methods

We conducted a population-based, nested, case-control study using health care data from Ontario for the period April 2002 to March 2011. We identified cases as outpatients aged 66 years or older with no history of liver disease, and who were admitted to hospital for acute liver injury within 30 days of receiving a prescription for 1 of 5 broad-spectrum antibiotic

SUBMITTER: Paterson JM 

PROVIDER: S-EPMC3470619 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature