The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders.
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ABSTRACT:
SUBMITTER: Bacon C
PROVIDER: S-EPMC3470686 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
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The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders.
Bacon Claire C Rappold Gudrun A GA
Human genetics 20120627 11
Rare disruptions of FOXP2 have been strongly implicated in deficits in language development. Research over the past decade has suggested a role in the formation of underlying neural circuits required for speech. Until recently no evidence existed to suggest that the closely related FOXP1 gene played a role in neurodevelopmental processes. However, in the last few years, novel rare disruptions in FOXP1 have been reported in multiple cases of cognitive dysfunction, including intellectual disabilit ...[more]
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