Genome-wide association study of a quantitative disordered gambling trait.
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ABSTRACT:
SUBMITTER: Lind PA
PROVIDER: S-EPMC3470766 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Genome-wide association study of a quantitative disordered gambling trait.
Lind Penelope A PA Zhu Gu G Montgomery Grant W GW Madden Pamela A F PA Heath Andrew C AC Martin Nicholas G NG Slutske Wendy S WS
Addiction biology 20120711 3
Disordered gambling is a moderately heritable trait, but the underlying genetic basis is largely unknown. We performed a genome-wide association study (GWAS) for disordered gambling using a quantitative factor score in 1312 twins from 894 Australian families. Association was conducted for 2 381 914 single-nucleotide polymorphisms (SNPs) using the family-based association test in Merlin followed by gene and pathway enrichment analyses. Although no SNP reached genome-wide significance, six achieve ...[more]
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