Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding.
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ABSTRACT:
SUBMITTER: Holmes A
PROVIDER: S-EPMC3471649 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding.
Holmes Andrew A Fitzgerald Paul J PJ MacPherson Kathryn P KP DeBrouse Lauren L Colacicco Giovanni G Flynn Shaun M SM Masneuf Sophie S Pleil Kristen E KE Li Chia C Marcinkiewcz Catherine A CA Kash Thomas L TL Gunduz-Cinar Ozge O Camp Marguerite M
Nature neuroscience 20120902 10
Alcoholism is frequently co-morbid with post-traumatic stress disorder, but it is unclear how alcohol affects the neural circuits mediating recovery from trauma. We found that chronic intermittent ethanol (CIE) impaired fear extinction and remodeled the dendritic arbor of medial prefrontal cortical (mPFC) neurons in mice. CIE impaired extinction encoding by infralimbic mPFC neurons in vivo and functionally downregulated burst-mediating NMDA GluN1 receptors. These findings suggest that alcohol ma ...[more]
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