Ontology highlight
ABSTRACT:
SUBMITTER: Alvarez Y
PROVIDER: S-EPMC3471763 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Alvarez Yolanda Y Rodríguez Mario M Municio Cristina C Hugo Etzel E Alonso Sara S Ibarrola Nieves N Fernández Nieves N Crespo Mariano Sánchez MS
The Journal of biological chemistry 20120814 42
Stimulation of human dendritic cells with the fungal surrogate zymosan produces IL-23 and a low amount of IL-12 p70. Trans-repression of il12a transcription, which encodes IL-12 p35 chain, by proteins of the Notch family and lysine deacetylation reactions have been reported as the underlying mechanisms, but a number of questions remain to be addressed. Zymosan produced the location of sirtuin 1 (SIRT1) to the nucleus, enhanced its association with the il12a promoter, increased the nuclear concen ...[more]