Ontology highlight
ABSTRACT:
SUBMITTER: Ott M
PROVIDER: S-EPMC3471855 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Ott Martina M Litzenburger Ulrike M UM Sahm Felix F Rauschenbach Katharina J KJ Tudoran Ruxandra R Hartmann Christian C Marquez Victor E VE von Deimling Andreas A Wick Wolfgang W Platten Michael M
PloS one 20121015 10
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the Polycomb-repressive complex 2 (PRC2) that epigenetically silences gene transcription through histone H3 lysine trimethylation (H3K27me3). EZH2 has been implicated in stem cell maintenance and is overexpressed in hematological and solid malignancie`s including malignant glioma. EZH2 is thought to promote tumor progression by silencing tumor suppressor genes. Hence pharmacological disruption of the PRC2 is an attractive therapeutic ...[more]