Ontology highlight
ABSTRACT:
SUBMITTER: Alloway RR
PROVIDER: S-EPMC3472020 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Alloway R R RR Sadaka B B Trofe-Clark J J Wiland A A Bloom R D RD
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20120703 10
Pharmacokinetic analyses comparing generic tacrolimus preparations versus the reference drug in kidney transplant patients are lacking. A prospective, multicenter, open-label, randomized, two-period (14 days per period), two-sequence, crossover and steady-state pharmacokinetic study was undertaken to compare twice-daily generic tacrolimus (Sandoz) versus reference tacrolimus (Prograf®) in stable renal transplant patients. AUC(0-12h) and peak concentration (C(max) ) were calculated from 12 h pha ...[more]