Ontology highlight
ABSTRACT:
SUBMITTER: Schnetz-Boutaud NC
PROVIDER: S-EPMC3472126 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Schnetz-Boutaud Nathalie C NC Hoffman Joshua J Coe Jared E JE Murdock Deborah G DG Pericak-Vance Margaret A MA Haines Jonathan L JL
Annals of human genetics 20120904 6
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory and cognitive impairment and is the leading cause of dementia in the elderly. A number of genome wide association studies and subsequent replication studies have been published recently on late onset AD (LOAD). These studies identified several new susceptibility genes including phosphatidylinositol-binding clathrin assembly protein (PICALM) on chromosome 11. The aim of our study was to examine the entire ...[more]