Unknown

Dataset Information

0

Association between the ABO locus and hematological traits in Korean.


ABSTRACT: BACKGROUND: Recently, genome-wide association studies identified a pleiotropic gene locus, ABO, as being significantly associated with hematological traits. To confirm the effects of ABO on hematological traits, we examined the link between the ABO locus and hematological traits in Korean population-based cohorts. RESULTS: Six tagging SNPs for ABO were analyzed with regard to their effects on hematological traits [white blood cell count (WBC), red blood cell count (RBC), platelet (Plat), mean corpuscular volume (MCV), and mean corpuscular haemoglobin concentration (MCHC)]. Linear regression analyses were performed, controlling for recruitment center, sex, and age as covariates. Of the 6 tagging SNPs, 3 (rs2073823, rs8176720, and rs495828) and 3 (rs2073823, rs8176717, and rs687289) were significantly associated with RBC and MCV, respectively (Bonferroni correction p-value criteria?

SUBMITTER: Hong KW 

PROVIDER: S-EPMC3472170 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

altmetric image

Publications

Association between the ABO locus and hematological traits in Korean.

Hong Kyung-Won KW   Moon Sanghoon S   Kim Young Jin YJ   Kim Yun Kyoung YK   Kim Dong-Joon DJ   Kim Cheong-sik CS   Kim Sung Soo SS   Kim Bong-Jo BJ  

BMC genetics 20120910


<h4>Background</h4>Recently, genome-wide association studies identified a pleiotropic gene locus, ABO, as being significantly associated with hematological traits. To confirm the effects of ABO on hematological traits, we examined the link between the ABO locus and hematological traits in Korean population-based cohorts.<h4>Results</h4>Six tagging SNPs for ABO were analyzed with regard to their effects on hematological traits [white blood cell count (WBC), red blood cell count (RBC), platelet (P  ...[more]

Similar Datasets

| S-EPMC4674197 | biostudies-literature
| S-EPMC4452145 | biostudies-literature
| S-EPMC4182467 | biostudies-literature
| S-EPMC4262412 | biostudies-literature
| S-EPMC4900668 | biostudies-literature
| S-EPMC2992676 | biostudies-literature
| S-EPMC3986688 | biostudies-literature
| S-EPMC6279815 | biostudies-other
| S-EPMC5088374 | biostudies-literature
| S-EPMC4425549 | biostudies-literature