Ontology highlight
ABSTRACT:
SUBMITTER: van Werven FJ
PROVIDER: S-EPMC3472370 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
van Werven Folkert J FJ Neuert Gregor G Hendrick Natalie N Lardenois Aurélie A Buratowski Stephen S van Oudenaarden Alexander A Primig Michael M Amon Angelika A
Cell 20120906 6
The cell-fate decision leading to gametogenesis is essential for sexual reproduction. In S. cerevisiae, only diploid MATa/α but not haploid MATa or MATα cells undergo gametogenesis, known as sporulation. We find that transcription of two long noncoding RNAs (lncRNAs) mediates mating-type control of sporulation. In MATa or MATα haploids, expression of IME1, the central inducer of gametogenesis, is inhibited in cis by transcription of the lncRNA IRT1, located in the IME1 promoter. IRT1 transcripti ...[more]