Ontology highlight
ABSTRACT:
SUBMITTER: Simons BW
PROVIDER: S-EPMC3472417 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Simons Brian W BW Hurley Paula J PJ Huang Zhenhua Z Ross Ashley E AE Miller Rebecca R Marchionni Luigi L Berman David M DM Schaeffer Edward M EM
Developmental biology 20120830 2
Androgens initiate a complex network of signals within the UGS that trigger prostate lineage commitment and bud formation. Given its contributions to organogenesis in other systems, we investigated a role for canonical Wnt signaling in prostate development. We developed a new method to achieve complete deletion of beta-catenin, the transcriptional coactivator required for canonical Wnt signaling, in early prostate development. Beta-catenin deletion abrogated canonical Wnt signaling and yielded p ...[more]