Ontology highlight
ABSTRACT:
SUBMITTER: Muppidi A
PROVIDER: S-EPMC3472523 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Muppidi Avinash A Doi Kenichiro K Edwardraja Selvakumar S Drake Eric J EJ Gulick Andrew M AM Wang Hong-Gang HG Lin Qing Q
Journal of the American Chemical Society 20120904 36
Direct chemical modifications provide a simple and effective means to "translate" bioactive helical peptides into potential therapeutics targeting intracellular protein-protein interactions. We previously showed that distance-matching bisaryl cross-linkers can reinforce peptide helices containing two cysteines at the i and i+7 positions and confer cell permeability to the cross-linked peptides. Here we report the first crystal structure of a biphenyl-cross-linked Noxa peptide in complex with its ...[more]