Ontology highlight
ABSTRACT:
SUBMITTER: Rodrigues AB
PROVIDER: S-EPMC3472591 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20120919 21
Cell competition is a conserved mechanism that regulates organ size and shares properties with the early stages of cancer. In Drosophila, wing cells with increased Myc or with optimum ribosome function become supercompetitors that kill their wild-type neighbors (called losers) up to several cell diameters away. Here, we report that modulating STAT activity levels regulates competitor status. Cells lacking STAT become losers that are killed by neighboring wild-type cells. By contrast, cells with ...[more]