Ontology highlight
ABSTRACT:
SUBMITTER: Wisniewski JR
PROVIDER: S-EPMC3472694 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Wiśniewski Jacek R JR Ostasiewicz Paweł P Duś Kamila K Zielińska Dorota F DF Gnad Florian F Mann Matthias M
Molecular systems biology 20120101
We report a proteomic analysis of microdissected material from formalin-fixed and paraffin-embedded colorectal cancer, quantifying > 7500 proteins between patient matched normal mucosa, primary carcinoma, and nodal metastases. Expression levels of 1808 proteins changed significantly between normal and cancer tissues, a much larger fraction than that reported in transcript-based studies. Tumor cells exhibit extensive alterations in the cell-surface and nuclear proteomes. Functionally similar chan ...[more]