Ontology highlight
ABSTRACT:
SUBMITTER: Meister S
PROVIDER: S-EPMC3473092 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20111117 6061
Most malaria drug development focuses on parasite stages detected in red blood cells, even though, to achieve eradication, next-generation drugs active against both erythrocytic and exo-erythrocytic forms would be preferable. We applied a multifactorial approach to a set of >4000 commercially available compounds with previously demonstrated blood-stage activity (median inhibitory concentration < 1 micromolar) and identified chemical scaffolds with potent activity against both forms. From this sc ...[more]