Ontology highlight
ABSTRACT:
SUBMITTER: Redondo M
PROVIDER: S-EPMC3474265 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Redondo Miriam M Palomo Valle V Brea José J Pérez Daniel I DI Martín-Álvarez Rocío R Pérez Concepción C Paúl-Fernández Nuria N Conde Santiago S Cadavid María Isabel MI Loza María Isabel MI Mengod Guadalupe G Martínez Ana A Gil Carmen C Campillo Nuria E NE
ACS chemical neuroscience 20120808 10
A neural network model has been developed to predict the inhibitory capacity of any chemical structure to be a phosphodiesterase 7 (PDE7) inhibitor, a new promising kind of drugs for the treatment of neurological disorders. The numerical definition of the structures was achieved using CODES program. Through the validation of this neural network model, a novel family of 5-imino-1,2,4-thiadiazoles (ITDZs) has been identified as inhibitors of PDE7. Experimental extensive biological studies have dem ...[more]