Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution.
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ABSTRACT:
SUBMITTER: Callahan DJ
PROVIDER: S-EPMC3474318 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution.
Callahan Daniel J DJ Liu Wenge W Li Xinghai X Dreher Matthew R MR Hassouneh Wafa W Kim Minkyu M Marszalek Piotr P Chilkoti Ashutosh A
Nano letters 20120319 4
To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn(2+) and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensiti ...[more]
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