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Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution.


ABSTRACT: To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn(2+) and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control.

SUBMITTER: Callahan DJ 

PROVIDER: S-EPMC3474318 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution.

Callahan Daniel J DJ   Liu Wenge W   Li Xinghai X   Dreher Matthew R MR   Hassouneh Wafa W   Kim Minkyu M   Marszalek Piotr P   Chilkoti Ashutosh A  

Nano letters 20120319 4


To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn(2+) and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensiti  ...[more]

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