Ontology highlight
ABSTRACT:
SUBMITTER: Mou H
PROVIDER: S-EPMC3474327 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Mou Hongmei H Zhao Rui R Sherwood Richard R Ahfeldt Tim T Lapey Allen A Wain John J Sicilian Leonard L Izvolsky Konstantin K Musunuru Kiran K Cowan Chad C Rajagopal Jayaraj J
Cell stem cell 20120401 4
Deriving lung progenitors from patient-specific pluripotent cells is a key step in producing differentiated lung epithelium for disease modeling and transplantation. By mimicking the signaling events that occur during mouse lung development, we generated murine lung progenitors in a series of discrete steps. Definitive endoderm derived from mouse embryonic stem cells (ESCs) was converted into foregut endoderm, then into replicating Nkx2.1+ lung endoderm, and finally into multipotent embryonic lu ...[more]