NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity.
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ABSTRACT:
SUBMITTER: Larsen RS
PROVIDER: S-EPMC3474337 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity.
Larsen Rylan S RS Corlew Rebekah J RJ Henson Maile A MA Roberts Adam C AC Mishina Masayoshi M Watanabe Masahiko M Lipton Stuart A SA Nakanishi Nobuki N Pérez-Otaño Isabel I Weinberg Richard J RJ Philpot Benjamin D BD
Nature neuroscience 20110206 3
Recent evidence suggests that presynaptic-acting NMDA receptors (preNMDARs) are important for neocortical synaptic transmission and plasticity. We found that unique properties of the NR3A subunit enable preNMDARs to enhance spontaneous and evoked glutamate release and that NR3A is required for spike timing-dependent long-term depression in the juvenile mouse visual cortex. In the mature cortex, NR2B-containing preNMDARs enhanced neurotransmission in the absence of magnesium, indicating that pres ...[more]
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