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Bromophycoic acids: bioactive natural products from a Fijian red alga Callophycus sp.

ABSTRACT: Bioassay-guided fractionation of extracts from a Fijian red alga in the genus Callophycus resulted in the isolation of five new compounds of the diterpene-benzoate class. Bromophycoic acids A-E (1-5) were characterized by NMR and mass spectroscopic analyses and represent two novel carbon skeletons, one with an unusual proposed biosynthesis. These compounds display a range of activities against human tumor cell lines, malarial parasites, and bacterial pathogens including low micromolar suppression of MRSA and VREF.

SUBMITTER: Teasdale ME

PROVIDER: S-EPMC3474338 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Bromophycoic acids: bioactive natural products from a Fijian red alga Callophycus sp.

Teasdale Margaret E ME Shearer Tonya L TL Engel Sebastian S Alexander Troy S TS Fairchild Craig R CR Prudhomme Jacques J Torres Manuel M Le Roch Karine K Aalbersberg William W Hay Mark E ME Kubanek Julia J

The Journal of organic chemistry 20120905 18

Bioassay-guided fractionation of extracts from a Fijian red alga in the genus Callophycus resulted in the isolation of five new compounds of the diterpene-benzoate class. Bromophycoic acids A-E (1-5) were characterized by NMR and mass spectroscopic analyses and represent two novel carbon skeletons, one with an unusual proposed biosynthesis. These compounds display a range of activities against human tumor cell lines, malarial parasites, and bacterial pathogens including low micromolar suppressio ...[more]

PMID: 22920243

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