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Biocompatible hydrogels by oxime Click chemistry.

ABSTRACT: Oxime Click chemistry was used to form hydrogels that support cell adhesion. Eight-armed aminooxy poly(ethylene glycol) (PEG) was mixed with glutaraldehyde to form oxime-linked hydrogels. The mechanical properties, gelation kinetics, and water swelling ratios were studied and found to be tunable. It was also shown that gels containing the integrin ligand arginine-glycine-aspartic acid (RGD) supported mesenchymal stem cell (MSC) incorporation. High cell viability and proliferation of the encapsulated cells demonstrated biocompatibility of the material.

SUBMITTER: Grover GN

PROVIDER: S-EPMC3474544 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Biocompatible hydrogels by oxime Click chemistry.

Grover Gregory N GN Lam Jonathan J Nguyen Thi H TH Segura Tatiana T Maynard Heather D HD

Biomacromolecules 20120912 10

Oxime Click chemistry was used to form hydrogels that support cell adhesion. Eight-armed aminooxy poly(ethylene glycol) (PEG) was mixed with glutaraldehyde to form oxime-linked hydrogels. The mechanical properties, gelation kinetics, and water swelling ratios were studied and found to be tunable. It was also shown that gels containing the integrin ligand arginine-glycine-aspartic acid (RGD) supported mesenchymal stem cell (MSC) incorporation. High cell viability and proliferation of the encapsul ...[more]

PMID: 22970829

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2017-07-13 | GSE88749 | GEO

Click chemistry enables comprehensive preclinical evaluation of targeted epigenetic therapies [Click-Seq 1]

2017-07-13 | GSE88748 | GEO

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