Biocompatible hydrogels by oxime Click chemistry.

ABSTRACT: Oxime Click chemistry was used to form hydrogels that support cell adhesion. Eight-armed aminooxy poly(ethylene glycol) (PEG) was mixed with glutaraldehyde to form oxime-linked hydrogels. The mechanical properties, gelation kinetics, and water swelling ratios were studied and found to be tunable. It was also shown that gels containing the integrin ligand arginine-glycine-aspartic acid (RGD) supported mesenchymal stem cell (MSC) incorporation. High cell viability and proliferation of the encapsulated cells demonstrated biocompatibility of the material.

SUBMITTER: Grover GN 

PROVIDER: S-EPMC3474544 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature