Ontology highlight
ABSTRACT:
SUBMITTER: Hinke SA
PROVIDER: S-EPMC3474922 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Hinke Simon A SA Navedo Manuel F MF Ulman Allison A Whiting Jennifer L JL Nygren Patrick J PJ Tian Geng G Jimenez-Caliani Antonio J AJ Langeberg Lorene K LK Cirulli Vincenzo V Tengholm Anders A Dell'Acqua Mark L ML Santana L Fernando LF Scott John D JD
The EMBO journal 20120831 20
Endocrine release of insulin principally controls glucose homeostasis. Nutrient-induced exocytosis of insulin granules from pancreatic β-cells involves ion channels and mobilization of Ca(2+) and cyclic AMP (cAMP) signalling pathways. Whole-animal physiology, islet studies and live-β-cell imaging approaches reveal that ablation of the kinase/phosphatase anchoring protein AKAP150 impairs insulin secretion in mice. Loss of AKAP150 impacts L-type Ca(2+) currents, and attenuates cytoplasmic accumula ...[more]