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Asymmetric synthesis of trifluoromethylated amines via catalytic enantioselective isomerization of imines.

ABSTRACT: A new approach toward the asymmetric synthesis of optically active trifluoromethylated amines was enabled by an unprecedented, highly enantioselective catalytic isomerization of trifluoromethyl imines with a new chiral organic catalyst. Not only aryl but also alkyl trifluoromethylated amines could be obtained in high enantioselectivities.

SUBMITTER: Wu Y 

PROVIDER: S-EPMC3475161 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Asymmetric synthesis of trifluoromethylated amines via catalytic enantioselective isomerization of imines.

Wu Yongwei Y   Deng Li L  

Journal of the American Chemical Society 20120823 35

A new approach toward the asymmetric synthesis of optically active trifluoromethylated amines was enabled by an unprecedented, highly enantioselective catalytic isomerization of trifluoromethyl imines with a new chiral organic catalyst. Not only aryl but also alkyl trifluoromethylated amines could be obtained in high enantioselectivities. ...[more]

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