Ontology highlight
ABSTRACT:
SUBMITTER: Alessandri C
PROVIDER: S-EPMC3475261 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120726 11
Autophagy, the cytoprotection mechanism that takes place under metabolic impairment, has been implicated in the pathogenesis of autoimmunity. Here, we investigated the spontaneous and induced autophagic behavior of T lymphocytes from patients with systemic lupus erythematosus (SLE) compared with that of T lymphocytes from healthy donors by measuring the autophagy marker microtubule-associated protein 1 light chain 3 (LC3)-II. No significant differences in spontaneous autophagy were found between ...[more]