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The cellular functions of clathrin.

ABSTRACT: Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from donor membranes. The major type of coat used by the cell is composed of clathrin, a three-legged protein that can form lattice-like coats on membranes destined for trafficking. In this review, I outline what we know about clathrin and discuss some recent advances in understanding the basic biology of this fascinating molecule, which include building a molecular model of a clathrin lattice and discovery of a new function for clathrin that occurs during mitosis.

SUBMITTER: Royle SJ

PROVIDER: S-EPMC3475309 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature

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The cellular functions of clathrin.

Royle S J SJ

Cellular and molecular life sciences : CMLS 20060801 16

Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from donor membranes. The major type of coat used by the cell is composed of clathrin, a three-legged protein that can form lattice-like coats on membranes destined for trafficking. In this review, I outline what we know about clathrin and discuss some recent advances in understanding the basic biology of this fascinating molecule, which include building a molecular model of a cla ...[more]

PMID: 16699812

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