Ontology highlight
ABSTRACT:
SUBMITTER: Wandler AM
PROVIDER: S-EPMC3475654 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Wandler Anica M AM Guillemin Karen K
PLoS pathogens 20121018 10
Gastric cancer development is strongly correlated with infection by Helicobacter pylori possessing the effector protein CagA. Using a transgenic Drosophila melanogaster model, we show that CagA expression in the simple model epithelium of the larval wing imaginal disc causes dramatic tissue perturbations and apoptosis when CagA-expressing and non-expressing cells are juxtaposed. This cell death phenotype occurs through activation of JNK signaling and is enhanced by loss of the neoplastic tumor s ...[more]