Ontology highlight
ABSTRACT:
SUBMITTER: Benndorf K
PROVIDER: S-EPMC3475657 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Benndorf Klaus K Kusch Jana J Schulz Eckhard E
PLoS computational biology 20121018 10
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are voltage-gated tetrameric cation channels that generate electrical rhythmicity in neurons and cardiomyocytes. Activation can be enhanced by the binding of adenosine-3',5'-cyclic monophosphate (cAMP) to an intracellular cyclic nucleotide binding domain. Based on previously determined rate constants for a complex Markovian model describing the gating of homotetrameric HCN2 channels, we analyzed probability fluxes within this ...[more]