Ontology highlight
ABSTRACT:
SUBMITTER: Kuhn DJ
PROVIDER: S-EPMC3476538 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Kuhn Deborah J DJ Berkova Zuzana Z Jones Richard J RJ Woessner Richard R Bjorklund Chad C CC Ma Wencai W Davis R Eric RE Lin Pei P Wang Hua H Madden Timothy L TL Wei Caimiao C Baladandayuthapani Veerabhadran V Wang Michael M Thomas Sheeba K SK Shah Jatin J JJ Weber Donna M DM Orlowski Robert Z RZ
Blood 20120829 16
Proteasome inhibition with bortezomib is a validated approach to the treatment of multiple myeloma, but drug resistance often emerges and limits its utility in the retreatment setting. To begin to identify some of the mechanisms involved, we developed bortezomib-resistant myeloma cell lines that, unlike previously reported models, showed no β5 subunit mutations. Instead, up-regulation of the insulin-like growth factor (IGF)-1 axis was identified, with increased autocrine and paracrine secretion ...[more]