Ontology highlight
ABSTRACT:
SUBMITTER: Li K
PROVIDER: S-EPMC3476947 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Li Kelin K Frankowski Kevin J KJ Belon Craig A CA Neuenswander Ben B Ndjomou Jean J Hanson Alicia M AM Shanahan Matthew A MA Schoenen Frank J FJ Blagg Brian S J BS Aubé Jeffrey J Frick David N DN
Journal of medicinal chemistry 20120322 7
A screen for hepatitis C virus (HCV) NS3 helicase inhibitors revealed that the commercial dye thioflavine S was the most potent inhibitor of NS3-catalyzed DNA and RNA unwinding in the 827-compound National Cancer Institute Mechanistic Set. Thioflavine S and the related dye primuline were separated here into their pure components, all of which were oligomers of substituted benzothiazoles. The most potent compound (P4), a benzothiazole tetramer, inhibited unwinding >50% at 2 ± 1 μM, inhibited the ...[more]