Ontology highlight
ABSTRACT:
SUBMITTER: Danino T
PROVIDER: S-EPMC3477096 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Danino Tal T Lo Justin J Prindle Arthur A Hasty Jeff J Bhatia Sangeeta N SN
ACS synthetic biology 20120921 10
The engineering of bacteria to controllably deliver therapeutics is an attractive application for synthetic biology. While most synthetic gene networks have been explored within microbes, there is a need for further characterization of in vivo circuit behavior in the context of applications where the host microbes are actively being investigated for efficacy and safety, such as tumor drug delivery. One major hurdle is that culture-based selective pressures are absent in vivo, leading to strain-d ...[more]