Ontology highlight
ABSTRACT:
SUBMITTER: Palagani V
PROVIDER: S-EPMC3477166 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Palagani Vindhya V El Khatib Mona M Kossatz Uta U Bozko Przemyslaw P Müller Martin R MR Manns Michael P MP Krech Till T Malek Nisar P NP Plentz Ruben R RR
PloS one 20121019 10
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a high rate of metastasis. Recent studies have indicated that the Notch signalling pathway is important in PDAC initiation and maintenance, although the specific cell biological roles of the pathway remain to be established. Here we sought to examine this question in established pancreatic cancer cell lines using the γ-secretase inhibitor IX (GSI IX) to inactivate Notch. Based on the known roles of Notch in development and ste ...[more]