Ontology highlight
ABSTRACT:
SUBMITTER: Jin UH
PROVIDER: S-EPMC3477220 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Jin Un-Ho UH Lee Syng-ook SO Safe Stephen S
The Journal of pharmacology and experimental therapeutics 20120809 2
Leflunomide, flutamide, nimodipine, mexiletine, sulindac, tranilast, 4-hydroxytamoxifen, and omeprazole are pharmaceuticals previously characterized as aryl hydrocarbon receptor (AHR) agonists in various cell lines and animal models. In this study, the eight AHR-active pharmaceuticals were investigated in highly aggressive aryl hydrocarbon (Ah)-responsive BT474 and MDA-MB-468 breast cancer cell lines, and their effects on AHR protein, CYP1A1 (protein and mRNA), CYP1B1 (mRNA), and cell migration ...[more]