Ontology highlight
ABSTRACT:
SUBMITTER: Suderman M
PROVIDER: S-EPMC3477392 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Suderman Matthew M McGowan Patrick O PO Sasaki Aya A Huang Tony C T TC Hallett Michael T MT Meaney Michael J MJ Turecki Gustavo G Szyf Moshe M
Proceedings of the National Academy of Sciences of the United States of America 20121008
Early life experience is associated with long-term effects on behavior and epigenetic programming of the NR3C1 (GLUCOCORTICOID RECEPTOR) gene in the hippocampus of both rats and humans. However, it is unlikely that such effects completely capture the evolutionarily conserved epigenetic mechanisms of early adaptation to environment. Here we present DNA methylation profiles spanning 6.5 million base pairs centered at the NR3C1 gene in the hippocampus of humans who experienced abuse as children and ...[more]