Ontology highlight
ABSTRACT:
SUBMITTER: Jin X
PROVIDER: S-EPMC3477867 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Nature 20100701 7305
Learning new action sequences subserves a plethora of different abilities such as escaping a predator, playing the piano, or producing fluent speech. Proper initiation and termination of each action sequence is critical for the organization of behaviour, and is compromised in nigrostriatal disorders like Parkinson's and Huntington's diseases. Using a self-paced operant task in which mice learn to perform a particular sequence of actions to obtain an outcome, we found neural activity in nigrostri ...[more]