Ontology highlight
ABSTRACT:
SUBMITTER: Ramadan E
PROVIDER: S-EPMC3478068 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Ramadan Epolia E Basselin Mireille M Chang Lisa L Chen Mei M Ma Kaizong K Rapoport Stanley I SI
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20120704 3
HIV-1 transgenic (Tg) rats, a model for human HIV-1 associated neurocognitive disorder (HAND), show upregulated markers of brain arachidonic acid (AA) metabolism with neuroinflammation after 7 months of age. Since lithium decreases AA metabolism in a rat lipopolysaccharide model of neuroinflammation, and may be useful in HAND, we hypothesized that lithium would dampen upregulated brain AA metabolism in HIV-1 Tg rats. Regional brain AA incorporation coefficients k* and rates J ...[more]