Ontology highlight
ABSTRACT:
SUBMITTER: Song H
PROVIDER: S-EPMC3478149 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Song Hang H Kaiser Jens T JT Barton Jacqueline K JK
Nature chemistry 20120610 8
DNA mismatches represent a novel target in the development of diagnostics and therapeutics for cancer, because deficiencies in DNA mismatch repair are implicated in cancers, and cells that are repair-deficient show a high frequency of mismatches. Metal complexes with bulky intercalating ligands serve as probes for DNA mismatches. Here, we report the high-resolution (0.92 Å) crystal structure of the ruthenium 'light switch' complex Δ-[Ru(bpy)(2)dppz](2+) (bpy = 2,2'-bipyridine and dppz = dipyrido ...[more]